DBRD 9-A

DBRD 9-A is a PROTAC which can selective degrade BRD9. dBRD 9-A improves the bromine domain binding profile and reduces the binding activity of the whole BET family[1].

Product Specifications

CAS Number

[2170679-42-0]

UNSPSC

12352005

Hazard Statement

H301-H360

Target

Epigenetic Reader Domain; PROTACs

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dbrd-9-a.html

Purity

99.50

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C2=C(C(C3=CC(OC)=C(CN(CC(NCCCCCCCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C)C(OC)=C3)=CN1C)C=CN=C2

Molecular Formula

C42H49N7O8

Molecular Weight

779.88

Precautions

P264-P270-P280-P330-P405-P501

References & Citations

[1]Remillard D, et al. Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands. Angew Chem Int Ed Engl. 2017 May 15;56 (21) :5738-5743.|[2]Ye ZHENG, et al. WO2022183056A1. 2022.