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ARTD10/PARP10-IN-2

ARTD10/PARP10-IN-2 (compound 19) is a potent and non-selective PARP inhibitor, targeting to mono-ADP-ribosyltransferases ARTD10/PARP10 and poly (ADP-ribose) polymerase-1 ARTD1/PARP1 with IC50s of 2.0 μM, and 9.7 μM, respectively[1].

Product Specifications

CAS Number

1708103-69-8

UNSPSC

12352005

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/artd10-parp10-in-2.html

Solubility

10 mM in DMSO

Smiles

CNC(/C=C\C(NC1=CC(C(N)=O)=CC=C1)=O)=O

Molecular Formula

C12H13N3O3

Molecular Weight

247.25

References & Citations

[1]Ekblad T, et al. Towards small molecule inhibitors of mono-ADP-ribosyltransferases. Eur J Med Chem. 2015 May 5;95:546-51.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PARP1; PARP10; PARP14; PARP15

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