2MD

2MD is an orally active vitamin D analog. 2MD stimulates periosteal bone formation and decreases trabecular bone resorption. Thus 2MD restores trabecular and cortical bone mass and strength. 2MD also regulates intraocular pressure (IOP) -relative genes and reduces IOP in non-human primates[1][2].

Product Specifications

CAS Number

[213250-70-5]

UNSPSC

12352211

Target

VD/VDR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/2md.html

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@](CC[C@]2([H])[C@@H](C)CCCC(C)(O)C)([H])/C(CCC1)=C/C=C3C[C@H](C([C@@H](C\3)O)=C)O

Molecular Formula

C27H44O3

Molecular Weight

416.64

References & Citations

[1]Kutuzova GD, et al. 1α,25-Dihydroxyvitamin D (3) and its analog, 2-methylene-19-nor- (20S) -1α,25-dihydroxyvitamin D (3) (2MD), suppress intraocular pressure in non-human primates. Arch Biochem Biophys. 2012 Feb 1;518 (1) :53-60. |[2]Ke HZ, et al. A new vitamin D analog, 2MD, restores trabecular and cortical bone mass and strength in ovariectomized rats with established osteopenia. J Bone Miner Res. 2005 Oct;20 (10) :1742-55.