Gly-Cyclopropane-Exatecan
Gly-Cyclopropane-Exatecan involves in the synthesis of anti-B7-H4 ADC, containing Exatecan , a DNA Topoisomerase I inhibitor. Gly-Cyclopropane-Exatecan participated in the formation of the ADC hu2F7-Exatecan (compound 34), which showed antitumor activity in vivo and in vitro[1].
Product Specifications
CAS Number
2414254-49-0
UNSPSC
12352005
Target
ADC Payload; Topoisomerase
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gly-cyclopropane-exatecan.html
Solubility
10 mM in DMSO
Smiles
NCC(NCOC(C1CC1)C(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=O
Molecular Formula
C32H34FN5O7
Molecular Weight
619.64
References & Citations
[1]Hua Haiqing, et al. Anti-b7-h4 antibody-drug conjugate and medicinal use thereof: World Intellectual Property Organization, WO2020244657. 2020-12-10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Camptothecins
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