SPC4061
SPC4061 an antisense nucleotide, is a potent PCSK9 inhibitor. SPC4061 targets the lock-in nucleic acid (LNA) of PCSK9 for the study of hypercholesterolemia and related diseases[1][2].
Product Specifications
CAS Number
1018108-22-9
UNSPSC
12352208
Target
PCSK9
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/spc4061.html
Solubility
10 mM in DMSO
Smiles
[SPC4061]
References & Citations
[1]Li Chuan-Yuan, et al. PCSK9 inhibitor compositions and methods for the treatment of cancer associated with PCSK9 expression: World Intellectual Property Organization, WO2020005869 A2 2020-01-02. |[2]Lindholm MW, et al. PCSK9 LNA antisense oligonucleotides induce sustained reduction of LDL cholesterol in nonhuman primates. Mol Ther. 2012 Feb;20 (2) :376-81.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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