Mipomersen
Mipomersen (ISIS 301012 free base) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB) . Mipomersen has anti-HCV effect and reduces the infectivity of the HCV. Mipomersen can be used for the research of homozygous familial hypercholesterolemia (HoFH) [1][2].
Product Specifications
CAS Number
1000120-98-8
Product Name Alternative
ISIS 301012 (free base)
UNSPSC
12352208
Target
Apolipoprotein; HCV
Type
Oligonucleotides
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mipomersen.html
Purity
96.88
Solubility
H2O : ≥ 100 mg/mL
Smiles
[Mipomersen]
Molecular Formula
C230H324N67O122P19S19
Molecular Weight
7179.15
References & Citations
[1]Merki E, et al. Antisense oligonucleotide directed to human apolipoprotein B-100 reduces lipoprotein (a) levels and oxidized phospholipids on human apolipoprotein B-100 particles in lipoprotein (a) transgenic mice. Circulation. 2008 Aug 12;118 (7) :743-53.|[2]Schaefer EA, et al. Apolipoprotein B100 is required for hepatitis C infectivity and Mipomersen inhibits hepatitis C. World J Gastroenterol. 2016 Dec 7;22 (45) :9954-9965.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Launched
Isoform
ApoB
Citation 01
Poult Sci. 2025 Nov 19;105 (1) :106137.|Poult Sci. 2025 Mar 6;104 (5) :104993.
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