BTK-IN-23

BTK-IN-23 is a BTK inhibitor (IC50: 12.8 nM) . BTK-IN-23 also inhibits BLX and BMX with IC50s of 35.6 and 5.7 nM respectively. BTK-IN-23 shows improved kinase selectivity compared to Ibrutinib (HY-10997) [1].

Product Specifications

CAS Number

[2573048-11-8]

UNSPSC

12352005

Target

Btk

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/btk-in-23.html

Solubility

10 mM in DMSO

Smiles

C=CC(N1CCC[C@H](C1)N2N=C(C3=C(N=CN=C32)N)C4=C(C)C=C(C=C4C)OC5=CC=CC=C5)=O

Molecular Formula

C27H28N6O2

Molecular Weight

468.55

References & Citations

[1]Sean T. Toenjes, et al. Controlling Ibrutinib’s Conformations about Its Heterobiaryl Axis to Increase BTK Selectivity. ACS Med. Chem. Lett. 2023. https://doi.org/10.1021/acsmedchemlett.2c00523