BTK-IN-23
Product Specifications
UNSPSC Description
BTK-IN-23 is a BTK inhibitor (IC50: 12.8 nM). BTK-IN-23 also inhibits BLX and BMX with IC50s of 35.6 and 5.7 nM respectively. BTK-IN-23 shows improved kinase selectivity compared to Ibrutinib (HY-10997)[1].
Target Antigen
Btk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/btk-in-23.html
Solubility
10 mM in DMSO
Smiles
C=CC(N1CCC[C@H](C1)N2N=C(C3=C(N=CN=C32)N)C4=C(C)C=C(C=C4C)OC5=CC=CC=C5)=O
Molecular Weight
468.55
References & Citations
[1]Sean T. Toenjes, et al. Controlling Ibrutinib’s Conformations about Its Heterobiaryl Axis to Increase BTK Selectivity. ACS Med. Chem. Lett. 2023. https://doi.org/10.1021/acsmedchemlett.2c00523
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-148594/BTK-IN-23-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-148594/
Clinical Information
No Development Reported
CAS Number
2573048-11-8
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