Q-FTAA

Q-FTAA binds to Aβ1-42 fibrils with EC50 values of 330-630, 300-500 nM for Aβ1-42 fibrils, alzheimer's disease PIB binding complex (ADPBC), respectively. q-FTAA has the potential for the research of Alzheimer's disease (AD) [1].

Product Specifications

CAS Number

[1352477-22-5]

UNSPSC

12352005

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/q-ftaa.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=C(C2=CC(CC(O)=O)=C(C3=CC=C(C4=C(CC(O)=O)C=CS4)S3)S2)S1)O

Molecular Formula

C21H14O6S4

Molecular Weight

490.59

References & Citations

[1]Bäck M, et al. Anionic Oligothiophenes Compete for Binding of X-34 but not PIB to Recombinant Aβ Amyloid Fibrils and Alzheimer's Disease Brain-Derived Aβ. Chemistry. 2016 Dec 19;22 (51) :18335-18338.