β2AR/M-receptor agonist-1
β2AR/M-receptor agonist-1 (example 131) is a muscarinic antagonist and β2 adrenoceptor agonist (MABA) . β2AR/M-receptor agonist-1 shows potency to β2 adrenoceptor with an EC50 value of 9.2 nM. β2AR/M-receptor agonist-1 also has potency to muscarinic receptor with a Ki value of 30.2 nM. β2AR/M-receptor agonist-1 shows MABA potency with an EC50 value of 4.0 nM[1].
Product Specifications
CAS Number
[2230520-62-2]
UNSPSC
12352005
Target
Adrenergic Receptor; mAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/β2ar-m-receptor-agonist-1.html
Solubility
10 mM in DMSO
Smiles
O[C@@H](C1=C2C(NC(C=C2)=O)=C(C=C1)O)CNCCCOC(C=C3)=CC=C3OCCC[N+]45C[C@H](C(CC5)CC4)OC[C@@](C6CCCC6)(C7=CC=CC=C7)O.[Br-]
Molecular Formula
C43H56BrN3O7
Molecular Weight
806.82
References & Citations
[1]WEN SHOUMING, et al. CLASS OF BIFUNCTIONAL COMPOUNDS WITH QUATERNARY AMMONIUM SALT STRUCTURE. WO2018108089. 2018.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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