Nrf2 activator-6
Nrf2 activator-6, a tetrahydroisoquinoline compound, is a Nrf2 activator. Nrf2 activator-6 has an IC50 of 5 nM for inhibiting the Kelch domain-Nrf2 interaction (WO2021214470A1; Example 4) [1].
Product Specifications
CAS Number
[2728780-74-1]
UNSPSC
12352005
Target
Keap1-Nrf2; Quinone Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/nrf2-activator-6.html
Purity
98.15
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC([C@@](C)(CCC1)[C@@H]1C(N2[C@H](CN3C(CC4(C3)CC4)=O)C5=C(C(F)=CC(Cl)=C5CC2)OCC6=C7N(CCCC7)N=N6)=O)=O
Molecular Formula
C31H37ClFN5O5
Molecular Weight
614.11
References & Citations
[1]Cathy Louise LUCAS, et al. Tetrahydroisoquinoline compounds as nrf2 activators. WO2021214470A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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