Avacincaptad pegol
Avacincaptad pegol, which is a pegylated aptamer, has garnered significant attention as a C5 complement inhibitor that may reduce inflammation-related retinal pigment epithelium (RPE) damage. Avacincaptad pegol caqn be used for the research of stargardt macular dystrophy (STGD1) and geographic atrophy (GA) [1][2].
Product Specifications
CAS Number
[1613641-69-2]
Product Name Alternative
Izervay
UNSPSC
12352208
Target
Complement System
Type
Oligonucleotides
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/avacincaptad-pegol.html
Solubility
10 mM in DMSO
Smiles
[Avacincaptadpegol]
Molecular Weight
52603 (Approximately)
References & Citations
[1]Rehan M Hussain, et al. Stargardt macular dystrophy and evolving therapies. Expert Opin Biol Ther. 2018 Oct;18 (10) :1049-1059.|[2]Glenn J Jaffe, et al. C5 Inhibitor Avacincaptad Pegol for Geographic Atrophy Due to Age-Related Macular Degeneration: A Randomized Pivotal Phase 2/3 Trial. Ophthalmology. 2021 Apr;128 (4) :576-586.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
Launched
Curated Selection
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