Avacincaptad pegol

Avacincaptad pegol, which is a pegylated aptamer, has garnered significant attention as a C5 complement inhibitor that may reduce inflammation-related retinal pigment epithelium (RPE) damage. Avacincaptad pegol caqn be used for the research of stargardt macular dystrophy (STGD1) and geographic atrophy (GA) [1][2].

Product Specifications

CAS Number

[1613641-69-2]

Product Name Alternative

Izervay

UNSPSC

12352208

Target

Complement System

Type

Oligonucleotides

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/avacincaptad-pegol.html

Solubility

10 mM in DMSO

Smiles

[Avacincaptadpegol]

Molecular Weight

52603 (Approximately)

References & Citations

[1]Rehan M Hussain, et al. Stargardt macular dystrophy and evolving therapies. Expert Opin Biol Ther. 2018 Oct;18 (10) :1049-1059.|[2]Glenn J Jaffe, et al. C5 Inhibitor Avacincaptad Pegol for Geographic Atrophy Due to Age-Related Macular Degeneration: A Randomized Pivotal Phase 2/3 Trial. Ophthalmology. 2021 Apr;128 (4) :576-586.