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CDN-A

CDN-A is a cyclic di-nucleotide, it can be used to synthesis antibody-drug conjugate (ADC) . Cyclic di-nucleotides are potent stimulators of innate and adaptive immune responses. In humans, cyclic di-nucleotide, which are either produced endogenously in response to foreign DNA or by invading bacterial pathogens, trigger the innate immune system by activating the expression of interferon genes[1][2][3].

Product Specifications

CAS Number

2586047-09-6

UNSPSC

12352005

Target

STING

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cdn-a.html

Solubility

10 mM in DMSO

Smiles

O=P(O)(O[C@H]1[C@@H](O)[C@H](N(C=N2)C3=C2C(N)=NC=N3)O[C@@H]1COP4(O)=O)OC[C@@H](O5)[C@@H](CCN)[C@@H](O4)[C@@H]5N6C=NC7=C6N=C(N)NC7=O

Molecular Formula

C22H29N11O12P2

Molecular Weight

701.48

References & Citations

[1]Chen, Zhijian, et al. Antinbody-sting agonist conjugates and their use in immunotherapy. US 2021/0015941 Al. 2021.|[2]Lirussi D, et al. Type I IFN and not TNF, is Essential for Cyclic Di-nucleotide-elicited CTL by a Cytosolic Cross-presentation Pathway. EBioMedicine. 2017 Aug;22:100-111.|[3]Schaap P. Cyclic di-nucleotide signaling enters the eukaryote domain. IUBMB Life. 2013 Nov;65 (11) :897-903.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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