Abetimus
Abetimus (LJP 394 free base) is an immunosuppressant consisting of four double-stranded DNA (dsDNA) oligonucleotides. Abetimus is capable of crosslinking anti-dsDNA antibodies on the surface of B cells, and decreases anti-dsDNA antibodies levels. Abetimus has the potential for research of systemic lupus erythematosus[1].
Product Specifications
CAS Number
167362-48-3
Product Name Alternative
LJP 394 (free base)
UNSPSC
12352208
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/abetimus.html
Solubility
10 mM in DMSO
Smiles
[Abetimus]
Molecular Formula
C1632H2100N610O970P156S4
Molecular Weight
50742.05
References & Citations
[1]Marta Mosca, et al. LJP-394 (abetimus sodium) in the treatment of systemic lupus erythematosus. Expert Opin Pharmacother. 2007 Apr;8 (6) :873-9.|[2]S M Coutts, et al. Pharmacological intervention in antibody mediated disease. Lupus. 1996 Apr;5 (2) :158-9.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
Phase 3
Frequently Asked Questions
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