UCK2 Inhibitor-2

UCK2 Inhibitor-2 is a non-competitive uridine-cytidine kinase 2 (UCK2) inhibitor with an IC50 value of 3.8 μM. UCK2 Inhibitor-2 can suppress uridine salvage in cells[1].

Product Specifications

CAS Number

[866842-71-9]

UNSPSC

12352005

Target

Dihydroorotate Dehydrogenase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/uck2-inhibitor-2.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC(NC(CSC2=C3CC4=C(C(C)=CC=C4)OC3=NC(C5=CC=C(C)C=C5)=N2)=O)=CC=C1)O

Molecular Formula

C28H23N3O4S

Molecular Weight

497.56

References & Citations

[1]Ayse Okesli-Armlovich, et al. Discovery of small molecule inhibitors of human uridine-cytidine kinase 2 by high-throughput screening. Bioorg Med Chem Lett. 2019 Sep 15;29 (18) :2559-2564.