UCK2 Inhibitor-2
UCK2 Inhibitor-2 is a non-competitive uridine-cytidine kinase 2 (UCK2) inhibitor with an IC50 value of 3.8 μM. UCK2 Inhibitor-2 can suppress uridine salvage in cells[1].
Product Specifications
CAS Number
[866842-71-9]
UNSPSC
12352005
Target
Dihydroorotate Dehydrogenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/uck2-inhibitor-2.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(NC(CSC2=C3CC4=C(C(C)=CC=C4)OC3=NC(C5=CC=C(C)C=C5)=N2)=O)=CC=C1)O
Molecular Formula
C28H23N3O4S
Molecular Weight
497.56
References & Citations
[1]Ayse Okesli-Armlovich, et al. Discovery of small molecule inhibitors of human uridine-cytidine kinase 2 by high-throughput screening. Bioorg Med Chem Lett. 2019 Sep 15;29 (18) :2559-2564.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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