Etamicastat
Etamicastat (BIA 5-453) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor with an IC50 value of 107 nM[1]. Etamicastat can be used in the research of cardiovascular diseases[2].
Product Specifications
CAS Number
[760173-05-5]
Product Name Alternative
BIA 5-453
UNSPSC
12352005
Target
Dopamine β-hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Etamicastat.html
Solubility
10 mM in DMSO
Smiles
S=C1NC=C(CCN)N1[C@H]2COC3=C(C=C(F)C=C3F)C2
Molecular Formula
C14H15F2N3OS
Molecular Weight
311.35
References & Citations
[1]Loureiro AI, et al. Etamicastat, a new dopamine-ß-hydroxylase inhibitor, pharmacodynamics and metabolism in rat. Eur J Pharmacol. 2014 Oct 5;740:285-94.|[2]ManuelVaz-da-Silva, et al. Cardiac safety profile of etamicastat, a novel peripheral selective dopamine-β-hydroxylase inhibitor in non-human primates, human young and elderly healthy volunteers and hypertensive patients. IJC Metabolic & Endocrine. 2015 Jun; (7) : 10-24
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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