Abiraterone N-oxide

Abiraterone N-oxide is a metabolite of Abiraterone (HY-148377) . Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity[1].

Product Specifications

CAS Number

[2378463-76-2]

UNSPSC

12352005

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/abiraterone-n-oxide.html

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@](CC=C2C3=C[N+]([O-])=CC=C3)([H])[C@@]4([H])[C@]([C@@]5(C(C[C@H](CC5)O)=CC4)C)([H])CC1

Molecular Formula

C24H31NO2

Molecular Weight

365.51

References & Citations

[1]Hu Y, Huang J, et al. Simultaneous determination of abiraterone and its five metabolites in human plasma by LC-MS/MS: Application to pharmacokinetic study in healthy Chinese subjects. J Pharm Biomed Anal. 2022 Aug 5;217:114826.