HVEGF-IN-2
HVEGF-IN-2 (compound 19) is a selective VEGF (Flk-1) receptor tyrosine kinases (RTK) inhibitor with an IC50 value of 2.5 μM. hVEGF-IN-2 inhibits PDGF RTK activity with an IC50 value of 33.1 μM. hVEGF-IN-2 can be used for the development of RTK-specific agents[1].
Product Specifications
CAS Number
186610-88-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hvegf-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C1NC2=C(C=CC=C2)/C1=C/C3=CC=C(N4CCOCC4)C=C3
Molecular Formula
C19H18N2O2
Molecular Weight
306.36
Precautions
H302, H315, H319
References & Citations
[1]Sun L, et al. Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J Med Chem. 1998 Jul 2;41 (14) :2588-603.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR1/Flt-1
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