PD-1/PD-L1-IN-28

PD-1/PD-L1-IN-28 (compound 3) is an immune checkpoint inhibitor of PD-1/PD-L1 signaling pathway (IC50=0.744 µM) . PD-1/PD-L1-IN-28 shows good research potential in tumor immunity[1].

Product Specifications

CAS Number

[2499965-07-8]

UNSPSC

12352005

Target

PD-1/PD-L1

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pd-1-pd-l1-in-28.html

Solubility

10 mM in DMSO

Smiles

OCCNCC1=CC=C(NC2=NN=C(C3=C(C)C(C4=CC=CC=C4)=CC=C3)O2)C=C1

Molecular Formula

C24H24N4O2

Molecular Weight

400.47

References & Citations

[1]Jiang Sheng, et al. Preparation of phenyl substituted five membered heterocyclic compounds as immunocheckpoint inhibitors of PD-1 / PD-L1 signaling pathway. Patent WO2021031788A1.