Afegostat (D-Tartrate)
Afegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity[1].
Product Specifications
CAS Number
[957230-65-8]
Product Name Alternative
D-Isofagomine (D-Tartrate) ; Isofagomine (D-Tartrate)
UNSPSC
12352005
Hazard Statement
H225, H350
Target
Glycosidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Afegostat_D-Tartrate.html
Purity
98.0
Solubility
H2O : ≥ 50 mg/mL
Smiles
OC[C@@H]1[C@H]([C@@H](CNC1)O)O.OC([C@@H](O)[C@H](O)C(O)=O)=O
Molecular Formula
C10H19NO9
Molecular Weight
297.26
Precautions
H225, H350
References & Citations
[1]Richter F, et al. A GCase chaperone improves motor function in a mouse model of synucleinopathy. Neurotherapeutics. 2014 Oct;11 (4) :840-56.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 2
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