Afacifenacin
Afacifenacin (SMP-986) is a potent and orally active muscarinic receptor antagonist. Afacifenacin inhibits the bladder afferent pathway through the sodium-channel blockade, increasing volume, and reducing the frequency of urination and incontinence. Afacifenacin has the potential for the research of overactive bladder (OAB) [1][2].
Product Specifications
CAS Number
877606-63-8
Product Name Alternative
SMP-986
UNSPSC
12352005
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/afacifenacin.html
Solubility
10 mM in DMSO
Smiles
O=C1NC2=C(C=CC=C2)[C@H](C3=CC=CC=C3)N1C4CCN(CC5=CC=CC(OC(F)(F)F)=C5)CC4
Molecular Formula
C27H26F3N3O2
Molecular Weight
481.51
References & Citations
[1]Yeo EK, et al. New therapies in the treatment of overactive bladder. Expert Opin Emerg Drugs. 2013 Sep;18 (3) :319-37. |[2]Natsuko Goto, et al. Dual inhibition of Na+-channel and muscarinic receptor by SMP-986 efficiently improved voiding function compared to anti-muscarinic agents in two conscious rat models of detrusor overactivity. The Journal of Urology. 2008, 179, 129.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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