KTX-612
KTX-612 is an orally active IRAK4 PROTAC degrader with a DC50 value of 7 nM. KTX-612 can be used for the research of oncology[1]. (Pink:IRAK4 inhibitor ; Black: linker; Blue: CRBN Ligand (HY-10984) )
Product Specifications
CAS Number
2573298-14-1
UNSPSC
12352005
Target
IRAK; PROTACs
Type
Reference compound
Related Pathways
Immunology/Inflammation; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ktx-612.html
Solubility
10 mM in DMSO
Smiles
CC(C)(O)C1=CC2=NN(C=C2C=C1NC(C3=CC=CC(C(F)(F)F)=N3)=O)[C@H](CC4)CC[C@@H]4CN(CC5)CCC5(C6)CC6CNC7=C8C(C(N(C9C(NC(CC9)=O)=O)C8=O)=O)=CC=C7
Molecular Formula
C46H51F3N8O6
Molecular Weight
868.94
References & Citations
[1]Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IRAK4
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