KTX-497
KTX-497 is an IRAK4 PROTAC degrader with a DC50 value of 3 nM. KTX-497 can be used for the research of oncology[1]. (Pink:IRAK4 inhibitor (HY-150735) ; Black: linker; Blue: CRBN Ligand (HY-10984) )
Product Specifications
CAS Number
[2432993-46-7]
UNSPSC
12352005
Target
IRAK; PROTACs
Type
Reference compound
Related Pathways
Immunology/Inflammation; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ktx-497.html
Solubility
10 mM in DMSO
Smiles
O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(NC4CC5(CCN(CC5)C[C@@H]6CC[C@@H](N7C=C8C(C=C(C(NC(C9=CC=CC(C(F)(F)F)=N9)=O)=C8)C(C)(O)C)=N7)CC6)C4)=C3C1=O
Molecular Formula
C45H49F3N8O6
Molecular Weight
854.92
References & Citations
[1]Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IRAK4
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