KTX-497
KTX-497 is an IRAK4 PROTAC degrader with a DC50 value of 3 nM. KTX-497 can be used for the research of oncology[1]. (Pink:IRAK4 inhibitor ; Black: linker; Blue: CRBN Ligand (HY-10984) )
Product Specifications
CAS Number
2432993-46-7
UNSPSC
12352005
Target
IRAK; PROTACs
Type
Reference compound
Related Pathways
Immunology/Inflammation; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ktx-497.html
Solubility
10 mM in DMSO
Smiles
O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(NC4CC5(CCN(CC5)C[C@@H]6CC[C@@H](N7C=C8C(C=C(C(NC(C9=CC=CC(C(F)(F)F)=N9)=O)=C8)C(C)(O)C)=N7)CC6)C4)=C3C1=O
Molecular Formula
C45H49F3N8O6
Molecular Weight
854.92
References & Citations
[1]Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IRAK4
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS7229722-01 48 Well
Human Olfactory receptor 6B1 (OR6B1) ELISA Kit
Sign In for Pricing
View Details MBS7229722-02 96 Well
Human Olfactory receptor 6B1 (OR6B1) ELISA Kit
Sign In for Pricing
View Details MBS7229722-03 5x 96 Well
Human Olfactory receptor 6B1 (OR6B1) ELISA Kit
Sign In for Pricing
View Details MBS7229722-04 10x 96 Well
Human Olfactory receptor 6B1 (OR6B1) ELISA Kit
Sign In for Pricing
View Details 
128481 100 µg
ILF2 (Interleukin Enhancer-binding Factor 2, Nuclear Factor of Activated T-cells 45kD, NF45, PRO3063, MGC8391)
Sign In for Pricing
View Details