Zicronapine
Zicronapine is an antipsychotic medication with a strong pro-cognitive effect in animal models and the potential to treat a number of neurological and psychiatric diseases. Zicronapine has potent antagonistic effects at dopamine D1/D2, and serotonin 5-HT2A receptors.
Product Specifications
CAS Number
170381-16-5
Product Name Alternative
Lu 31-130
UNSPSC
12352005
Target
5-HT Receptor; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/zicronapine.html
Solubility
10 mM in DMSO
Smiles
CC1(C)N(C)CCN([C@@H]2C[C@@H](C3=CC=CC=C3)C4=C2C=C(Cl)C=C4)C1
Molecular Formula
C22H27ClN2
Molecular Weight
354.92
References & Citations
[1]Lopez De Diego, Heidi. et al. Succinate and malonate salts of trans-4- (1R,3S) -6-chloro-3-phenylindan-1-yl) -1,2,2-trimethylpiperazine and their preparation, pharmaceutical compositions, and use as medicaments, particularly as antipsychotics. WO2005016900A1|[2]Lundbeck H. A/S. The clinical phase III programme commenced on zicronapine. 20 Jan 2011.|[3]Lundbeck H, A/S. Zicronapine shows significant positive data in clinical phase II in the treatment of patients with schizophrenia –planning for continued clinical work. Press release No. 392 18 December 2009.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
5-HT2 Receptor
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