Zicronapine

Zicronapine is an antipsychotic medication with a strong pro-cognitive effect in animal models and the potential to treat a number of neurological and psychiatric diseases. Zicronapine has potent antagonistic effects at dopamine D1/D2, and serotonin 5-HT2A receptors.

Product Specifications

CAS Number

[170381-16-5]

Product Name Alternative

Lu 31-130

UNSPSC

12352005

Target

5-HT Receptor; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/zicronapine.html

Solubility

10 mM in DMSO

Smiles

CC1(C)N(C)CCN([C@@H]2C[C@@H](C3=CC=CC=C3)C4=C2C=C(Cl)C=C4)C1

Molecular Formula

C22H27ClN2

Molecular Weight

354.92

References & Citations

[1]Lopez De Diego, Heidi. et al. Succinate and malonate salts of trans-4- (1R,3S) -6-chloro-3-phenylindan-1-yl) -1,2,2-trimethylpiperazine and their preparation, pharmaceutical compositions, and use as medicaments, particularly as antipsychotics. WO2005016900A1|[2]Lundbeck H. A/S. The clinical phase III programme commenced on zicronapine. 20 Jan 2011.|[3]Lundbeck H, A/S. Zicronapine shows significant positive data in clinical phase II in the treatment of patients with schizophrenia –planning for continued clinical work. Press release No. 392 18 December 2009.