ADRA1D receptor antagonist 1 (free base)
Product Specifications
UNSPSC Description
ADRA1D receptor antagonist 1 (free base) (compound (R)-9s) is an orally active, potent and selective human α1D-adrenoceptor (α1D-AR) antagonist (Ki=1.6 nM). ADRA1D receptor antagonist 1 (free base) dose-dependently inhibits bladder contraction with an IC30 value of 15 nM. ADRA1D receptor antagonist 1 (free base) can be used in studies of overactive bladder disorders such as urinary urgency, frequency and incontinence.
Target Antigen
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/adra1d-receptor-antagonist-1-free-base.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(Cl)=CN([C@@H](C2=CC=CC(C#N)=C2)C)C1=N)N
Molecular Weight
300.74
References & Citations
[1]Sakauchi N, et al. Discovery of 5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide (TAK-259) as a Novel, Selective, and Orally Active α1D Adrenoceptor Antagonist with Antiurinary Frequency Effects: Reducing Human Ether-a-go-go-Related Gene (hERG) Liabilities. J Med Chem. 2016 Apr 14;59(7):2989-3002.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-148252/ADRA1D-receptor-antagonist-1-free-base-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-148252/
Clinical Information
No Development Reported
CAS Number
1191908-24-3
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
BNC402921-100 100 µL
Anti-Uroplakin 1A (Urothelial Differentiation Marker)(UPK1A/2921), CF640R conjugate
Ask
View Details 
MBS1237946-01 0.02 mg (E-Coli)
Recombinant Macaca fascicularis Proteasome activator complex subunit 1 (PSME1)
Ask
View Details MBS1237946-02 0.1 mg (E-Coli)
Recombinant Macaca fascicularis Proteasome activator complex subunit 1 (PSME1)
Ask
View Details 
MBS1237946-03 0.02 mg (Yeast)
Recombinant Macaca fascicularis Proteasome activator complex subunit 1 (PSME1)
Ask
View Details MBS1237946-04 0.1 mg (Yeast)
Recombinant Macaca fascicularis Proteasome activator complex subunit 1 (PSME1)
Ask
View Details