TP-050

TP-050, a chemical probe, is a potent, orally active and selective NMDAR agonist with an EC50 value of 0.51 μM and 9.6 μM for GluN2A and GluN2D, respecticely. TP-050 can cross the blood-brain barrier (BBB) . TP-050 induces hippocampal long-term (LPT) potentiation enhancemen and enhances neuronal signal transmission[1].

Product Specifications

CAS Number

[3085030-47-0]

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tp-050.html

Solubility

10 mM in DMSO

Smiles

CC1=CN(C(C2=CC(CN3N=C(C=C3Cl)C(F)F)=NN12)=O)[C@@H](CC#N)C

Molecular Formula

C16H15ClF2N6O

Molecular Weight

380.78

References & Citations

[1]Sakurai F, et, al. Discovery of Pyrazolo[1,5-a]pyrazin-4-ones as Potent and Brain Penetrant GluN2A-Selective Positive Allosteric Modulators Reducing AMPA Receptor Binding Activity. Bioorg Med Chem. 2022 Feb 15;56:116576.