BI-2081
BI-2081, a chemical probe, is a GPR40 (FFAR1) partial agonist (EC50: 4 nM) . BI-2081 induces glucose depending insulin secretion and reduces the plasma glucose concentration. BI-2081 can be used in the research of metabolic diseases, in particular diabetes type 2[1].
Product Specifications
CAS Number
1458656-71-7
UNSPSC
12352005
Target
Free Fatty Acid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/bi-2081.html
Solubility
10 mM in DMSO
Smiles
FC1=C(C(CC2)=C(C3=C(C=C(C=C3C)OCCC(C)(O)C)C)C=C1)[C@@H]2OC4=CC=C([C@@H](CO5)CC(O)=O)C5=C4
Molecular Formula
C32H35FO6
Molecular Weight
534.62
References & Citations
[1]Governa P, et al. FFAR1/GPR40: One target, different binding sites, many agonists, no drugs, but a continuous and unprofitable tug-of-war between ligand lipophilicity, activity, and toxicity. Bioorg Med Chem Lett. 2021 Jun 1;41:127969.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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