A-446
A-446, a chemical probe, is a potent glutaminase (GLS) inhibitor with an IC50 value of 31 nM[1].
Product Specifications
UNSPSC
12352005
Target
Glutaminase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/a-446.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=NN=C(S1)N2[C@H](C3)CN(C4=CC=CN=C4)[C@H]3C2)CC5=CC=CC=C5
Molecular Formula
C20H20N6OS
Molecular Weight
392.48
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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