JNJ-54119936
JNJ-54119936, a chemical probe, is a RORγ (RORc) inverse agonist (Kd=5.3 nM) [1][2].
Product Specifications
CAS Number
1599531-55-1
UNSPSC
12352005
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jnj-54119936.html
Solubility
10 mM in DMSO
Smiles
O[C@@](C1CCN(CC1)C(C)=O)(C2=CC=CC=C2)C3=CC4=C(N=C(C(CC5=CC=C(N6C=CC=N6)C=C5)=C4Cl)OC)C=C3
Molecular Formula
C34H33ClN4O3
Molecular Weight
581.10
References & Citations
[1]Barbay JK, et al. 6-Substituted quinolines as RORγt inverse agonists. Bioorg Med Chem Lett. 2017 Dec 1;27 (23) :5277-5283.|[2]https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/JNJ-54119936
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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