TP-051
TP-051, a chemical probe, is a potent FFAR1 agonist with an Ki value of 16 nM for human FFAR1. TP-051 can increase insulin secretion in rat insulinoma cells. TP-051 can be used to research type 2 diabetes[1].
Product Specifications
CAS Number
858097-86-6
UNSPSC
12352005
Target
Free Fatty Acid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/tp-051.html
Solubility
10 mM in DMSO
Smiles
O=C(CCC1=CC=C(C=C1F)OCC2=CC=CC(C3=C(C)C=C(C=C3C)OC4CCS(=O)(CC4)=O)=C2)O
Molecular Formula
C29H31FO6S
Molecular Weight
526.62
References & Citations
[1]Mikami S, et al. Discovery of phenylpropanoic acid derivatives containing polar functionalities as potent and orally bioavailable G protein-coupled receptor 40 agonists for the treatment of type 2 diabetes. J Med Chem. 2012 Apr 26;55 (8) :3756-76.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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