Tolindate

Tolindate is a potent PXR agonist with an EC50 value of 8.3 μM. Tolindate shows antifungal activity[1][2].

Product Specifications

CAS Number

[27877-51-6]

UNSPSC

12352005

Target

Fungal; Pregnane X Receptor (PXR)

Type

Reference compound

Related Pathways

Anti-infection; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/tolindate.html

Solubility

10 mM in DMSO

Smiles

S=C(N(C)C1=CC=CC(C)=C1)OC2=CC=C3C(CCC3)=C2

Molecular Formula

C18H19NOS

Molecular Weight

297.41

References & Citations

[1]Lynch C, et al. Characterization of human pregnane X receptor activators identified from a screening of the Tox21 compound library. Biochem Pharmacol. 2021 Feb;184:114368.|[2]Pastor L, et al. New antifungals selected by molecular topology. Bioorg Med Chem Lett. 1998 Sep 22;8 (18) :2577-82.