Tolindate
Tolindate is a potent PXR agonist with an EC50 value of 8.3 μM. Tolindate shows antifungal activity[1][2].
Product Specifications
CAS Number
[27877-51-6]
UNSPSC
12352005
Target
Fungal; Pregnane X Receptor (PXR)
Type
Reference compound
Related Pathways
Anti-infection; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/tolindate.html
Solubility
10 mM in DMSO
Smiles
S=C(N(C)C1=CC=CC(C)=C1)OC2=CC=C3C(CCC3)=C2
Molecular Formula
C18H19NOS
Molecular Weight
297.41
References & Citations
[1]Lynch C, et al. Characterization of human pregnane X receptor activators identified from a screening of the Tox21 compound library. Biochem Pharmacol. 2021 Feb;184:114368.|[2]Pastor L, et al. New antifungals selected by molecular topology. Bioorg Med Chem Lett. 1998 Sep 22;8 (18) :2577-82.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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