S- (p-Nitrobenzyl) glutathione

S- (p-Nitrobenzyl) glutathione is a competitive glutathionase inhibitor. S- (p-Nitrobenzyl) glutathione is converted to the corresponding cysteine derivatives by rat kidney microsomes. S- (p-Nitrobenzyl) glutathione can be used for the research of metabolic breakdown of glutathione by the glutathionase system[1][2].

Product Specifications

CAS Number

[6803-19-6]

UNSPSC

12352005

Target

Amino Acid Derivatives

Type

Reference compound

Related Pathways

Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/s-p-nitrobenzyl-glutathione.html

Purity

98.99

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC([C@@H](N)CCC(N[C@H](C(NCC(O)=O)=O)CSCC1=CC=C(C=C1)[N+]([O-])=O)=O)=O

Molecular Formula

C17H22N4O8S

Molecular Weight

442.44

References & Citations

[1]I García-Sáez, et al. Molecular structure at 1.8 A of mouse liver class pi glutathione S-transferase complexed with S- (p-nitrobenzyl) glutathione and other inhibitors. J Mol Biol. 1994 Apr 1;237 (3) :298-314. |[2]T Suga, et al. Studies on mercapturic acids. Participation of glutathionase in the conversion of glutathione derivatives to cysteine derivatives. J Biochem. 1966 Aug;60 (2) :133-9.