Tubulin polymerization-IN-38
Tubulin polymerization-IN-38 is an analogue of Tubulysin (HY-128914), a potent anticancer agent. Tubulin polymerization-IN-38 inhibits tubulin polymerization (tubulin polymerisation), thereby inducing apoptosis (apoptosis) . Tubulysin series products are potent anti-microtubule toxins (anti-microtubule toxins) and can be used as ADC cytotoxins (ADC Cytotoxin) to synthesize ADCs[1].
Product Specifications
CAS Number
[1005192-31-3]
UNSPSC
12352005
Target
ADC Payload; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulin-polymerization-in-38.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CSC([C@H](OC(C)=O)C[C@@H](N(C([C@@H](NC([C@@H]2N(C)CCCC2)=O)[C@@H](C)CC)=O)COC(CC(C)C)=O)C(C)C)=N1)O
Molecular Formula
C31H50N4O8S
Molecular Weight
638.82
References & Citations
[1]Jonathan A. Ellman, et al. Tubulysin d analogues. WO2009012958A2.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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