JNJ-3790339
JNJ-3790339, a Ritanserin (HY-10791) analog, is a potent and selective diacylglycerol kinase (DGKα) inhibitor with an IC50 of 9.6 μM. JNJ-3790339 has induction of toxicity in malignant cells, and improves ability to upregulate T cell activation[1].
Product Specifications
CAS Number
[93076-87-0]
UNSPSC
12352005
Target
DGK
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jnj-3790339.html
Solubility
10 mM in DMSO
Smiles
O=C1C(CCN2CC/C(CC2)=C(C3=CC=C(C)C=C3)\C4=CC=C(C)C=C4)=C(C)N=C5SC=C(C)N51
Molecular Formula
C30H33N3OS
Molecular Weight
483.67
References & Citations
[1]Granade ME, et al. Identification of ritanserin analogs that display DGK isoform specificity. Biochem Pharmacol. 2022 Mar;197:114908.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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