L-I-OddU

L-I-OddU, a L-5'-halo- dioxolane nucleoside analogue, is a potent and selective anti-Epstein-Barr virus (EBV) agent with an EC50 value of 0.03μM. L-I-OddU has low cytotoxicity with a CC50 value of 1000 nM. L-I-OddU has antiviral activity by suppressing replicative EBV DNA and viral protein synthesis[1][2].

Product Specifications

CAS Number

[207920-87-4]

UNSPSC

12352005

Target

DNA/RNA Synthesis; EBV; Nucleoside Antimetabolite/Analog

Type

Oligonucleotides

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/l-i-oddu.html

Solubility

10 mM in DMSO

Smiles

OC[C@@H]1O[C@H](N(C=C(C(N2)=O)I)C2=O)CO1

Molecular Formula

C8H9IN2O5

Molecular Weight

340.07

References & Citations

[1]Kira T, et, al. Anti-Epstein-Barr virus (EBV) activity of beta-L-5-iododioxolane uracil is dependent on EBV thymidine kinase. Antimicrob Agents Chemother. 2000 Dec;44 (12) :3278-84.|[2]Focher F, et, al. Antivirals at the mirror: the lack of stereospecificity of some viral and human enzymes offers novel opportunities in antiviral drug development. Curr Drug Targets Infect Disord. 2003 Mar;3 (1) :41-53.