MD13
MD13 is a macrophage migration inhibitory factor (MIF) -directed PROTAC with a Ki of 71 nM. MD13 can be used for cancer research[1].
Product Specifications
CAS Number
[2758431-97-7]
UNSPSC
12352005
Target
Macrophage migration inhibitory factor (MIF) ; PROTACs
Type
Reference compound
Related Pathways
Immunology/Inflammation; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/md13.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(N2C(OC3=CC(O)=CC=C3C2)=O)C=C1)CCCCCCCNC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O
Molecular Formula
C35H35N5O8
Molecular Weight
653.68
References & Citations
[1]Xiao Z, et al. Proteolysis Targeting Chimera (PROTAC) for Macrophage Migration Inhibitory Factor (MIF) Has Anti-Proliferative Activity in Lung Cancer Cells. Angew Chem Int Ed Engl. 2021 Aug 2;60 (32) :17514-17521.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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