PI4KIIIbeta-IN-11
PI4KIIIbeta-IN-11 is an inhibitor of PI4KIIIβ, with a mean pIC50 value of at least 9.1. PI4KIIIβ plays a key role in diseases research of RNA viruses and Plasmodium falciparum[1][2].
Product Specifications
CAS Number
2365241-79-6
UNSPSC
12352005
Target
PI4K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pi4kiiibeta-in-11.html
Solubility
10 mM in DMSO
Smiles
CN1C(C2=CC=CC(CNC3=CC(C(C)(O)C)=NC4=C(C5=CC(C(N(C)[C@@H](C)CO)=O)=C(C=C5)C)C(C)=NN34)=C2)=NC=C1
Molecular Formula
C33H39N7O3
Molecular Weight
581.71
References & Citations
[1]Kremer L, et al. Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß. Angew Chem Int Ed Engl. 2019 Nov 11;58 (46) :16617-16628. |[2]Barton Nicholas Paul, et al. Preparation of pyrazolopyrimidinamines derivatives as PI4kIII-beta inhibitors: World Intellectual Property Organization, WO2019141694. 2019-07-25.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI4KIIIβ
Frequently Asked Questions
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