PI4KIIIbeta-IN-11

PI4KIIIbeta-IN-11 is an inhibitor of PI4KIIIβ, with a mean pIC50 value of at least 9.1. PI4KIIIβ plays a key role in diseases research of RNA viruses and Plasmodium falciparum[1][2].

Product Specifications

CAS Number

[2365241-79-6]

UNSPSC

12352005

Target

PI4K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/pi4kiiibeta-in-11.html

Solubility

10 mM in DMSO

Smiles

CN1C(C2=CC=CC(CNC3=CC(C(C)(O)C)=NC4=C(C5=CC(C(N(C)[C@@H](C)CO)=O)=C(C=C5)C)C(C)=NN34)=C2)=NC=C1

Molecular Formula

C33H39N7O3

Molecular Weight

581.71

References & Citations

[1]Kremer L, et al. Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß. Angew Chem Int Ed Engl. 2019 Nov 11;58 (46) :16617-16628. |[2]Barton Nicholas Paul, et al. Preparation of pyrazolopyrimidinamines derivatives as PI4kIII-beta inhibitors: World Intellectual Property Organization, WO2019141694. 2019-07-25.