Plm IV inhibitor-1
Plm IV inhibitor-1 (compound 6) is a potent plasmepsin IV (Plm IV) inhibitor with IC50s of 4.1, 0.80, 0.25, 0.35 µM for Plm I, Plm II, Plm IV, Cat D, respectively[1].
Product Specifications
CAS Number
1539276-41-9
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/plm-iv-inhibitor-1.html
Solubility
10 mM in DMSO
Smiles
CCCN(CCC)C(C1=CC(C(N[C@H]([C@H](O)CNC(C)(C2=CC=CC=N2)C)CC3=CC=CC=C3)=O)=CC(N4CCCCC4)=C1)=O
Molecular Formula
C37H51N5O3
Molecular Weight
613.83
References & Citations
[1]Jaudzems K, et al. Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit. ACS Med Chem Lett. 2014 Jan 13;5 (4) :373-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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