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EGFR-IN-64

EGFR-IN-64 (Compound 3c) is a potent EGFR inhibitor with an IC50 of 0.33 μM. EGFR-IN-64 shows anticancer activity[1].

Product Specifications

CAS Number

2416924-93-9

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-in-64.html

Solubility

10 mM in DMSO

Smiles

O=C(N1N=C(/C=C/C2=CC=C(OC)C=C2)CC1C3=CC=C(OC)C=C3)N

Molecular Formula

C20H21N3O3

Molecular Weight

351.40

References & Citations

[1]George RF, et al. Some 1,3,5-trisubstituted pyrazoline derivatives targeting breast cancer: Design, synthesis, cytotoxic activity, EGFR inhibition and molecular docking. Bioorg Chem. 2020 Jun;99:103780.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

EGFR/ErbB1/HER1

Frequently Asked Questions

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