Aurora kinase inhibitor-10
Aurora kinase inhibitor-10 (Compound 6c) is an orally active Aurora B inhibitor with an IC50 of 8 nM. Aurora kinase inhibitor-10 shows antitumor activity[1].
Product Specifications
CAS Number
2417228-90-9
UNSPSC
12352005
Target
Aurora Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aurora-kinase-inhibitor-10.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=C(NC2=NC=C(F)C(N3CCNC4=CC(F)=CC=C4C3)=N2)C=C1)(N)=O.O=C(C(F)(F)F)O
Molecular Formula
C21H19F5N6O4S
Molecular Weight
546.47
References & Citations
[1]Tamizharasan N, et al. Discovery and optimization of novel phenyldiazepine and pyridodiazepine based Aurora kinase inhibitors. Bioorg Chem. 2020 Jun;99:103800.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora B
Frequently Asked Questions
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