HCA I-IN-1

HCA I-IN-1 (Compound 6q) is a human carbonic anhydrase I (hCA I) inhibitor with Ki values of 38.3, 716.4, 940.1 and 192.8 nM against hCA I, hCA II, hCAIX and hCAXII, respectively[1].

Product Specifications

CAS Number

[2417232-26-7]

UNSPSC

12352005

Target

Carbonic Anhydrase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hca-i-in-1.html

Solubility

10 mM in DMSO

Smiles

COC1=CC=CC(C(/C=C/C2=CN(C3=CC=CC=C23)CC4=CN(N=N4)C5=CC=C(C=C5)S(N)(=O)=O)=O)=C1

Molecular Formula

C27H23N5O4S

Molecular Weight

513.57

References & Citations

[1]Singh P, et al. Synthesis and carbonic anhydrase inhibition studies of sulfonamide based indole-1,2,3-triazole chalcone hybrids. Bioorg Chem. 2020 Jun;99:103839.