HCA I-IN-1
HCA I-IN-1 (Compound 6q) is a human carbonic anhydrase I (hCA I) inhibitor with Ki values of 38.3, 716.4, 940.1 and 192.8 nM against hCA I, hCA II, hCAIX and hCAXII, respectively[1].
Product Specifications
CAS Number
[2417232-26-7]
UNSPSC
12352005
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hca-i-in-1.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=CC(C(/C=C/C2=CN(C3=CC=CC=C23)CC4=CN(N=N4)C5=CC=C(C=C5)S(N)(=O)=O)=O)=C1
Molecular Formula
C27H23N5O4S
Molecular Weight
513.57
References & Citations
[1]Singh P, et al. Synthesis and carbonic anhydrase inhibition studies of sulfonamide based indole-1,2,3-triazole chalcone hybrids. Bioorg Chem. 2020 Jun;99:103839.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA II; CA I
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