PI3Kα-IN-8
PI3Kα-IN-8 (Compound 9g) is a selective PI3Kα inhibitor with an IC50 of 0.012 μM. PI3Kα-IN-8 increases intracellular reactive oxygen species level, decreases mitochondrial membrane potential and induces apoptosis[1].
Product Specifications
CAS Number
2315320-24-0
UNSPSC
12352005
Target
Apoptosis; PI3K; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi3kα-in-8.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12C3=CC(Br)=C(N=C(N4)NC5=CC=C(C=C5)C#N)C4=C3CC[C@@]1([H])[C@@](C)(CCC2)C(OC)=O
Molecular Formula
C26H27BrN4O2
Molecular Weight
507.42
References & Citations
[1]Yang YQ, et al. Synthesis and anticancer evaluation of novel 1H-benzo[d]imidazole derivatives of dehydroabietic acid as PI3Kα inhibitors. Bioorg Chem. 2020 Jul;100:103845.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
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