Tubulin polymerization-IN-31
Tubulin polymerization-IN-31 (Compound 4c) is a tubulin polymerization inhibitor with an IC50 of 3.64 μM. Tubulin polymerization-IN-31 induces cancer cell apoptosis and shows antitumor activity[1].
Product Specifications
CAS Number
2421121-79-9
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulin-polymerization-in-31.html
Solubility
10 mM in DMSO
Smiles
N#CC1=C2CCCCC2=C(C3=C(F)C=CC=C3Cl)C(C#N)=C1N
Molecular Formula
C18H13ClFN3
Molecular Weight
325.77
References & Citations
[1]Shaheen MA, et al. 1,4,5,6,7,8-Hexahydroquinolines and 5,6,7,8-tetrahydronaphthalenes: A new class of antitumor agents targeting the colchicine binding site of tubulin. Bioorg Chem. 2020 Jun;99:103831.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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