CXCR4 antagonist 8

CXCR4 antagonist 8 (Compound 3) is a CXCR4 antagonist with an IC50 of 57 nM. CXCR4 antagonist 8 inhibits CXCL12 induced cytosolic calcium increase with an IC50 of 0.24 nM. CXCR4 antagonist 8 inhibits CXLC12/CXCR4 mediated cell migration[1].

Product Specifications

CAS Number

[2304750-84-1]

UNSPSC

12352005

Target

CXCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/cxcr4-antagonist-8.html

Solubility

10 mM in DMSO

Smiles

CN1CCN(C2=CC(CN(C)C3=C4N=CC=CC4=CC=C3)=NC(C)=N2)CC1

Molecular Formula

C21H26N6

Molecular Weight

362.47

References & Citations

[1]Lin Y, et al. Design, synthesis, and evaluation of novel CXCR4 antagonists based on an aminoquinoline template. Bioorg Chem. 2020 Jun;99:103824.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CXCR4

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