CXCR4 antagonist 8
CXCR4 antagonist 8 (Compound 3) is a CXCR4 antagonist with an IC50 of 57 nM. CXCR4 antagonist 8 inhibits CXCL12 induced cytosolic calcium increase with an IC50 of 0.24 nM. CXCR4 antagonist 8 inhibits CXLC12/CXCR4 mediated cell migration[1].
Product Specifications
CAS Number
[2304750-84-1]
UNSPSC
12352005
Target
CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/cxcr4-antagonist-8.html
Solubility
10 mM in DMSO
Smiles
CN1CCN(C2=CC(CN(C)C3=C4N=CC=CC4=CC=C3)=NC(C)=N2)CC1
Molecular Formula
C21H26N6
Molecular Weight
362.47
References & Citations
[1]Lin Y, et al. Design, synthesis, and evaluation of novel CXCR4 antagonists based on an aminoquinoline template. Bioorg Chem. 2020 Jun;99:103824.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CXCR4
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